A convenient method for synthesis of 11 - [ 14 C ] - loxapine
نویسندگان
چکیده
Tricyclic ring systems, possessing the dibenzo structure joined to the central seven membered heterocyclic ring with a basic side chain, have been a rich source of biologically active molecular entities and frequently show effects on the central nervous system [10]. The precise mechanism of action of these compounds is not known [2]. Therefore to further elucidate the mechanism of action and to support ongoing metabolism studies, there arose a need for analogues of these compounds carbon-14 labeled in a biologically stable site. In our previous report [7], we reported a modified synthesis of 11-[C]-clozapine and in this paper a convenient method for the synthesis of 8-chloro-11-(4-methyl-1piperazinyl)-11-[C]-dibenz [b,f][1,4]oxazepine is described.
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